Modeling Atherosclerotic Plaques: Genesis, Growth, Remission and
Ultra-sound Detection and Classification
October 20, 2010
3:00pm SEC 204
Abstract
Atherosclerosis is a complex disease of the arterial system whose genesis
and progression involve an interplay of genetic, metabolic, inflammatory
and mechanical processes. In this talk, I survey recent results of modeling
and analysis of metabolic and inflammatory processes that play a key role
in atherogenesis, and then how mechanics must be accounted for to
understand plaque growth and disease remission. Additionally, I describe
preliminary modeling and analysis of the use of intravascular ultrasound
technologies for detecting and classifying vulnerable plaques. A key issue
addressed is gaining a deeper understanding of the mechanical significance
of arterial wall residual stress and developing an effective modeling
framework for taking account of residual stress in the use of intravascular
ultrasound interrogation of plaques.
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Last modified: April 11 2016 - 18:14:43